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ey0015.3-3 | Mechanisms of the year | ESPEYB15

3.3 Internalized TSH receptors en route to the TGN induce local Gs-protein signaling and gene transcription

A Godbole , S Lyga , MJ Lohse , D Calebiro

To read the full abstract: Nat Commun 2017;8:443G-protein-coupled receptors (GPCRs) are a large family of receptors localized at the cell membrane, detecting specific ligands such as hormones, neurotransmitters, odors, pheromones. Further, GCPRs are the main element for the photoisomerization process, necessary to convert a photon impulse to an electrical signal in photosensitive gan...

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ey0015.8-13 | New Genes | ESPEYB15

8.13 Activating PRKACB somatic mutation in cortisol-producing adenomas

S Espiard , MJ Knape , K Bathon , G Assié , M Rizk-Rabin , S Faillot , W Luscap-Rondof , D Abid , L Guignat , D Calebiro , FW Herberg , CA Stratakis , J Bertherat

To read the full abstract: JCI Insight. 2018; 3(8). pii: 98296Adrenocortical cells depend on cAMP/PKA signaling for growth and steroidogenesis. Several adrenal disorders manifesting with Cushing syndrome (CS) are due to activation of the PKA pathway, including Carney complex and primary pigmented nodular adrenal disease (due to germline mutations of PRKA1RA), McCune-Albright syndrome (due to ...

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ESPE Yearbook of Paediatric Endocrinology

3.3 Internalized TSH receptors en route to the TGN induce local Gs-protein signaling and gene transcription

8.13 Activating PRKACB somatic mutation in cortisol-producing adenomas

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